Cancer Susceptibility Genes
Visualizations using Graph Database Technology
See genes and their associated diseases as a network using graph database technology
View genes specific to a given specialty
Cancer Susceptibility Genes Visualizations using Graph Database Technology
This website provides visualizations of cancer susceptibility genes and gene combinations Pathogenic variants inherited at birth (Germline) in certain genes increase the risk of certain cancers. Cancer susceptibility genes can be better understood using a framework where each gene has:
- A spectrum of diseases caused
- A penetrance for each disease
- A predominant subtype of each disease
- An age of onset when risk begins to increase
When managing a patient with a pathogenic variant in a given gene, the spectrum of disease suggests which diseases and subtypes to address in our management plan and suggests what family history might suggest eligibility for testing. The penetrance suggests how aggressive to be in management. The age of onset suggests when to institute management.
Syndromes have often been defined before the underlying gene was identified. Syndromes can be useful in helping us remember certain family characteristics of certain genes.